Impact of rare and low-frequency sequence variants on reliability of genomic prediction in dairy cattle.

ABSTRACT:

Background

Availability of whole-genome sequence data for a large number of cattle and efficient imputation methodologies open a new opportunity to include rare and low-frequency variants (RLFV) in genomic prediction in dairy cattle. The objective of this study was to examine the impact of including RLFV that are within genes and selected from whole-genome sequence variants, on the reliability of genomic prediction for fertility, health and longevity in dairy cattle.

Results

All genic RLFV with a minor allele frequency lower than 0.05 were extracted from imputed sequence data and subsets were created using different strategies. These subsets were subsequently combined with Illumina 50 k single nucleotide polymorphism (SNP) data and used for genomic prediction. Reliability of

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6247626 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature