Metabolic Volumetric Parameters in ¹¹C-Choline PET/MR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer.

ABSTRACT:

Purpose

Positron emission tomography/magnetic resonance imaging (PET/MRI) can facilitate the use of noninvasive imaging biomarkers in clinical prostate cancer staging. Although multiparametric MRI is a widely used technique, the clinical value of simultaneous PET imaging remains unclear. This study aimed at investigating this issue.

Methods

Between January 2015 and December 2016, 31 high-risk prostate cancer patients underwent ¹¹C-choline PET/MRI for staging purposes. Clinical characteristics and imaging parameters, including the standardized uptake value (SUV) and metabolic volumetric parameters from PET imaging; apparent diffusion coefficient (ADC) values from diffusion-weighted imaging; and volume transfer rate constant (Ktrans), reflux rate constant (Kep), and

SUBMITTER: Tseng JR 

PROVIDER: S-EPMC6247714 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature