Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese.

ABSTRACT:

Background

Exposure to increased manganese (Mn) causes inflammation and neuronal injury in the cortex and basal ganglia, resulting in neurological symptoms resembling Parkinson's disease. The mechanisms underlying neuronal death from exposure to Mn are not well understood but involve inflammatory activation of microglia and astrocytes. Expression of neurotoxic inflammatory genes in glia is highly regulated through the NF-κB pathway, but factors modulating neurotoxic glial-glial and glial-neuronal signaling by Mn are not well understood.

Methods

We examined the role of NF-κB in Mn-induced neurotoxicity by exposing purified microglia, astrocytes (from wild-type and astrocyte-specific IKK knockout mice), and mixed glial cultures to varying Mn concentrations and then treating ne

SUBMITTER: Popichak KA 

PROVIDER: S-EPMC6247759 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature