Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.

ABSTRACT:

Importance

The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation.

Objective

To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics.

Design, setting, and participants

This multicenter analysis used pooled individual-level data from 758 592 premenopausal women from 19 p

SUBMITTER: Premenopausal Breast Cancer Collaborative Group 

PROVIDER: S-EPMC6248078 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature