Association of Transforming Growth Factor β Polymorphism C-509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Whether genetic factors can identify patients at risk for radiation-induced fibrosis remains unconfirmed.

Objective

To assess the association between the C-509T variant allele in the promoter region of TGFB1 and breast fibrosis 3 years after radiotherapy.

Design, setting, and participants

This is an a priori-specified, prospective, cohort study nested in an open-label, randomized clinical trial, which was conducted in community-based and academic cancer centers to compare hypofractionated whole-breast irradiation (WBI) (42.56 Gy in 16 fractions) with conventionally fractionated WBI (50 Gy in 25 fractions) after breast-conserving surgery. In total, 287 women 40 years or older with pathologically confirmed stage 0 to IIA breast cancer treated with breast-cons

SUBMITTER: Grossberg AJ 

PROVIDER: S-EPMC6248087 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature