Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial.

ABSTRACT:

Importance

Cannabidiol (CBD) has antipsychotic effects in humans, but how these are mediated in the brain remains unclear.

Objective

To investigate the neurocognitive mechanisms that underlie the therapeutic effects of CBD in psychosis.

Design, setting, and participants

In this parallel-group, double-blind, placebo-controlled randomized clinical trial conducted at the South London and Maudsley NHS Foundation Trust in London, United Kingdom, 33 antipsychotic medication-naive participants at clinical high risk (CHR) of psychosis and 19 healthy control participants were studied. Data were collected from July 2013 to October 2016 and analyzed from November 2016 to October 2017.

Interventions

A total of 16 participants at CHR of psychosis received a single oral dose

SUBMITTER: Bhattacharyya S 

PROVIDER: S-EPMC6248101 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature