Association of Inflammation and Disability Accrual in Patients With Progressive-Onset Multiple Sclerosis.

ABSTRACT:

Importance

The role of inflammatory disease activity as a determinant of disability in progressive-onset multiple sclerosis (MS) remains contested.

Objective

To examine the association of superimposed relapses in progressive-onset MS on disease outcomes.

Design, setting, and participants

Observational cohort study from MSBase, a prospectively collected, international database. Data were collected between January 1995 and February 2017. Analyses began in February 2017. From 44 449 patients at time of extraction, 1419 eligible patients (31.9%) were identified for analysis. Inclusion criteria consisted of primary progressive MS (PPMS) or progressive-relapsing MS (PRMS), adult-onset disease, and minimum data set (including ≥3 visits with disability recorded, ≥3 months bet

SUBMITTER: Hughes J 

PROVIDER: S-EPMC6248114 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature