Placebo Effects on the Neurologic Pain Signature: A Meta-analysis of Individual Participant Functional Magnetic Resonance Imaging Data.

ABSTRACT:

Importance

Placebo effects reduce pain and contribute to clinical analgesia, but after decades of research, it remains unclear whether placebo treatments mainly affect nociceptive processes or other processes associated with pain evaluation.

Objective

We conducted a systematic, participant-level meta-analysis to test the effect of placebo treatments on pain-associated functional neuroimaging responses in the neurologic pain signature (NPS), a multivariate brain pattern tracking nociceptive pain.

Data sources

Medline (PubMed) was searched from inception to May 2015; the search was augmented with results from previous meta-analyses and expert recommendations.

Study selection

Eligible studies were original investigations that were published in English in peer-revi

SUBMITTER: Zunhammer M 

PROVIDER: S-EPMC6248115 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature