Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders.

ABSTRACT:

Importance

Recent studies have reported a higher relapse rate following an initial inflammatory demyelinating disorder in pediatric patients with persistent seropositivity of antibodies targeting myelin oligodendrocyte glycoprotein (MOG-IgG1). To date, the clinical implications of longitudinal MOG-IgG1 seropositivity using live cell assays with IgG1 secondary antibodies in adults after acute disseminated encephalomyelitis (ADEM) are unknown.

Objective

To determine whether MOG-IgG1 serostatus (transient vs persistent) and titer change over time provide clinical utility in predicting the likelihood of relapse after ADEM.

Design, setting, and participants

This cohort study identified patients with an initial diagnosis of ADEM evaluated at a single referral center between

SUBMITTER: Lopez-Chiriboga AS 

PROVIDER: S-EPMC6248120 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature