Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43.

ABSTRACT:

Importance

Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele is strongly associated with β-amyloid (Aβ) aggregation and risk of AD, but its association with TDP-43 is unknown.

Objective

To determine whether the APOE ε4 allele is a risk factor for TDP-43.

Design, setting, participants

This cross-sectional, genetic-histologic study analyzed APOE genotype, TDP-43 status (positive vs negative), Aβ status (positive vs negative), and tau neurofibrillary tangle stage (B0, Braak stage 0; B1, Braak stages I-II; B2, Braak stages III-IV; B3, Braak stage ≥ V). We fit structural equation models to map the association between APOE and TDP-43, A

SUBMITTER: Wennberg AM 

PROVIDER: S-EPMC6248121 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature