Efficacy and Safety of Antibiotic Therapy in Early Cutaneous Lyme Borreliosis: A Network Meta-analysis.

ABSTRACT:

Importance

Controversies about the choice of antibiotic agent and treatment modality exist in the management of erythema migrans in early cutaneous Lyme borreliosis (LB).

Objective

To conduct a network meta-analysis (NMA) of all randomized clinical trials on various antibiotic agents and treatment modalities in early cutaneous LB.

Data sources

Electronic searches in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were conducted from inception until July 2017. The reference lists of the included studies were hand searched, authors were contacted, and ongoing trials were searched at ClinicalTrials.gov.

Study selection

One reviewer screened the titles and abstracts of the 9975 reports identified by the electronic searches. Full-text copies

SUBMITTER: Torbahn G 

PROVIDER: S-EPMC6248135 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature