Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial.

ABSTRACT:

Importance

It remains uncertain whether invasive ventilation should use low tidal volumes in critically ill patients without acute respiratory distress syndrome (ARDS).

Objective

To determine whether a low tidal volume ventilation strategy is more effective than an intermediate tidal volume strategy.

Design, setting, and participants

A randomized clinical trial, conducted from September 1, 2014, through August 20, 2017, including patients without ARDS expected to not be extubated within 24 hours after start of ventilation from 6 intensive care units in the Netherlands.

Interventions

Invasive ventilation using low tidal volumes (n = 477) or intermediate tidal volumes (n = 484).

Main outcomes and measures

The primary outcome was the number of ventilator-fr

SUBMITTER: Writing Group for the PReVENT Investigators 

PROVIDER: S-EPMC6248136 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature