Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings.

ABSTRACT:

Importance

Biomarker testing for asymptomatic, preclinical Alzheimer disease (AD) is invasive and expensive. Optical coherence tomographic angiography (OCTA) is a noninvasive technique that allows analysis of retinal and microvascular anatomy, which is altered in early-stage AD.

Objective

To determine whether OCTA can detect early retinal alterations in cognitively normal study participants with preclinical AD diagnosed by criterion standard biomarker testing.

Design, setting, and participants

This case-control study included 32 participants recruited from the Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St Louis, St Louis, Missouri. Results of extensive neuropsychometric testing determined that all participants were cogniti

SUBMITTER: O'Bryhim BE 

PROVIDER: S-EPMC6248182 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature