Association of Chronic Kidney Disease With Allopurinol Use in Gout Treatment.

ABSTRACT:

Importance

Clinicians are often cautious about use of allopurinol in patients with gout when renal function declines.

Objective

To assess the association of allopurinol use in gout with the risk of developing chronic kidney disease stage 3 or higher.

Design, setting, and participants

A time-stratified propensity score-matched, population-based, prospective cohort study of individuals with newly diagnosed gout who initiated allopurinol (≥300 mg/d) compared with those who did not initiate allopurinol, using the Health Improvement Network (THIN), a United Kingdom general practitioner electronic health records database, was carried out. The data were analyzed using Cox proportional hazards regression. Among adults aged 18 to 89 years with newly diagnosed gout, we propensi

SUBMITTER: Vargas-Santos AB 

PROVIDER: S-EPMC6248199 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature