Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis.

ABSTRACT: Background: Human visceral leishmaniasis, caused by infection with Leishmania donovani or L. infantum, is a potentially fatal disease affecting 50,000-90,000 people yearly in 75 disease endemic countries, with more than 20,000 deaths reported. Experimental models of infection play a major role in understanding parasite biology, host-pathogen interaction, disease pathogenesis, and parasite transmission. In addition, they have an essential role in the identification and pre-clinical evaluation of new drugs and vaccines. However, our understanding of these models remains fragmentary. Although the immune response to Leishmania donovani infection in mice has been extensively characterized, transcriptomic analysis capturing the tissue-specific evolution of disease has

SUBMITTER: Ashwin H 

PROVIDER: S-EPMC6248268 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature