MiR-125a-5p suppresses colorectal cancer progression by targeting VEGFA.

ABSTRACT:

Background

MiR-125a-5p has been reported to be involved in the development and progression of various cancers. However, the biological function and underlying mechanisms in colorectal cancer(CRC) still remain unclear. Here, we explored the potential biological roles of miR-125a-5p in CRC.

Methods

The expression of miR-125a-5p was detected using quantitative real-time PCR (qRT-PCR), biological functions of miR-125a-5p were assessed by cell counting kit-8, wound-healing, transwell invasion, and human umbilical vein endothelial cell (HUVEC) tube formation assays in vitro and animal experiments in vivo.

Results

We found that miR-125a-5p was downregulated in CRC tissues and cell lines, it inhibited CRC cell proliferation, migration, and invasion and reduced the ability of

SUBMITTER: Yang X 

PROVIDER: S-EPMC6248379 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature