CD24 expression and stem-associated features define tumor cell heterogeneity and tumorigenic capacities in a model of carcinogenesis.

ABSTRACT:

Background

Most carcinomas are composed of heterogeneous populations of tumor cells with distinct and apparently stable phenotypic characteristics.

Methods

Using an in vitro model of carcinogenesis we aimed at experimentally elucidating the significance of heterogeneity in the expression of CD24, a marker frequently overexpressed in various cancers and correlated with poor prognosis.

Results

We show that CD24^Neg and CD24^Pos cells issued from the same tumorigenic cell line display striking differences in stem-related properties, expression of epithelial-mesenchymal transition/mesenchymal-epithelial transition markers, and tumorigenic capacity. Indeed, while CD24^Neg cells were as tumorigenic as the parental cell line, CD24^Pos

SUBMITTER: Ortiz-Montero P 

PROVIDER: S-EPMC6248383 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature