Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro.

ABSTRACT: Streptococcus agalactiae (group B streptococcus [GBS]) infection in pregnant women is the leading cause of infectious neonatal morbidity and mortality in the United States. Although inflammation during infection has been associated with preterm birth, the contribution of GBS to preterm birth is less certain. Moreover, the early mechanisms by which GBS interacts with the gestational tissue to affect adverse pregnancy outcomes are poorly understood. We hypothesized that short-term GBS inoculation activates pathways related to inflammation and premature birth in human extraplacental membranes. We tested this hypothesis using GBS-inoculated human extraplacental membranes in vitro. In agreement with our hypothesis, a microarray-based transcriptomics analysis of gene expression changes in GBS-in

SUBMITTER: Park HR 

PROVIDER: S-EPMC6248496 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature