Simulating long-term human weight-loss dynamics in response to calorie restriction.

ABSTRACT:

Background

Mathematical models have been developed to predict body weight (BW) and composition changes in response to lifestyle interventions, but these models have not been adequately validated over the long term.

Objective

We compared mathematical models of human BW dynamics underlying 2 popular web-based weight-loss prediction tools, the National Institutes of Health Body Weight Planner (NIH BWP) and the Pennington Biomedical Research Center Weight Loss Predictor (PBRC WLP), with data from the 2-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study.

Design

Mathematical models were initialized using baseline CALERIE data, and changes in body weight (ΔBW), fat mass (ΔFM), and energy expenditure (ΔEE) were simulated in respons

SUBMITTER: Guo J 

PROVIDER: S-EPMC6248630 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature