Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny.

ABSTRACT: Summary:Copy number variation is an important and abundant source of variation in the human genome, which has been associated with a number of diseases, especially cancer. Massively parallel next-generation sequencing allows copy number profiling with fine resolution. Such efforts, however, have met with mixed successes, with setbacks arising partly from the lack of reliable analytical methods to meet the diverse and unique challenges arising from the myriad experimental designs and study goals in genetic studies. In cancer genomics, detection of somatic copy number changes and profiling of allele-specific copy number (ASCN) are complicated by experimental biases and artifacts as well as normal cell contamination and cancer subclone admixture. Furthermore, careful statistical modeling is w

SUBMITTER: Urrutia E 

PROVIDER: S-EPMC6248831 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature