Association between sleep-disordered breathing and breast cancer aggressiveness.

ABSTRACT:

Background

Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast cancer (BC) aggressiveness.

Methods

83 consecutive women <65 years diagnosed with primary BC underwent a home respiratory polygraphy. Markers of SDB severity included the apnea-hypopnea index (AHI) and the 4% oxygen desaturation index (ODI4). The Ki67 proliferation index, lack of hormone receptors (HR-), Nottingham Histological Grade (NHG), and tumor stage were used as markers of BC aggressiveness. The association between SDB and molecular subtypes of BC was also assessed.

Results

The mean (SD) age was 48.8 (8.8) years and body mass index was 27.4 (5.4)

SUBMITTER: Campos-Rodriguez F 

PROVIDER: S-EPMC6248981 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature