Fucoidans inhibit the formation of post-operative abdominal adhesions in a rat model.

ABSTRACT:

Purpose

Fibrin clot is essential for post-operative abdominal adhesion formation. Fucoidans, sulfated polysaccharides, inhibit fibrin clot formation. In addition, they inhibit inflammation and fibrosis, which also play important roles in adhesion formation. The purpose of this study was to evaluate fucoidans' potential for inhibiting post-operative abdominal adhesions and measure their effects on systemic coagulation parameters when administered intraperitoneally (IP).

Methods and materials

Female Sprague Dawley rats were studied. A 2.5x2.5cm full thickness segment of abdominal wall was excised. The skin edges were approximated. This model induces extensive adhesions and allows objective quantitation. Three fucoidans were evaluated- Sigma Fucoidan Crude (SFC), Fucus vesiculo

SUBMITTER: Charboneau AJ 

PROVIDER: S-EPMC6249019 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature