Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations.

ABSTRACT: Driver mutations are the genetic variants responsible for oncogenesis, but how specific somatic mutational events arise in cells remains poorly understood. Mutational signatures derive from the frequency of mutated trinucleotides in a given cancer sample, and they provide an avenue for investigating the underlying mutational processes that operate in cancer. Here we analyse somatic mutations from 7,815 cancer exomes from The Cancer Genome Atlas (TCGA) across 26 cancer types. We curate a list of 50 known cancer driver mutations by analysing recurrence in our cohort and annotations of known cancer-associated genes from the Cancer Gene Census, IntOGen database and Cancer Genome Interpreter. We then use these datasets to perform binary univariate logistic regression and establish the statistic

SUBMITTER: Poulos RC 

PROVIDER: S-EPMC6249022 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature