Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection.

ABSTRACT: CD4+ T cells play predominant roles in protective immunity against blood-stage Plasmodium infection, both for IFN-γ-dependent effector mechanisms and providing B cell helper signals. Neddylation, an ubiquitination-like process triggered by covalent conjugation of NEDD8 to specific targets, has emerged as a potential regulator of T cell activities to TCR engagement. However, its contribution to T cell-mediated immunity to blood-stage malaria remains unclear. Here using an experimental model induced by Plasmodium yoelii 17XNL, and conditional knockout mice with T cell-specific deficiency of crucial components of neddylation pathway, we demonstrate activation of neddylation in T cells during blood-stage Plasmodium infection is essential for parasite control and host survival. Mechanistically,

SUBMITTER: Cheng Q 

PROVIDER: S-EPMC6249024 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature