Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model.

ABSTRACT:

Background

Fanconi anemia is an inherited bone marrow failure disorder associated with a high incidence of leukemia and solid tumors. Currently, no interventions to prevent or delay the formation of solid tumors are available.

Procedure

Two of the most important hallmarks of Fanconi anemia are inflammation and oxidative stress. In this study, we administrated the antioxidant atorvastatin and the anti-inflammatory drug celecoxib to cohorts of Fancd2^-/- /Trp53^+/- mice, a model of Fanconi anemia. Treatment started at weaning and continued until the mice developed a palpable mass or suffered from >20% weight loss. Tumor samples and selected tissues were subjected to histopathological examination. χ² test was performed to analyze tumor incidence,

SUBMITTER: Zhang QS 

PROVIDER: S-EPMC6249055 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature