Salvage regimens for pediatric patients with relapsed nasopharyngeal carcinoma.

ABSTRACT: There is no established salvage regimen for pediatric patients with relapsed nasopharyngeal carcinoma (NPC) and outcomes are dismal. We performed a multicenter retrospective review to determine outcomes after first salvage therapy for pediatric patients with relapsed NPC. Fourteen patients were treated with varied regimens. Two of the 14 patients received oxaliplatin-containing regimens and achieved a long-term complete response. Although definitive recommendations cannot be made based on outcomes for 14 patients who received varied regimens, we discuss justification for an oxaliplatin-containing regimen in combination with gemcitabine as a reasonable choice for first-line salvage therapy for pediatric patients with relapsed NPC.

SUBMITTER: DeRenzo C 

PROVIDER: S-EPMC6249063 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature