Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group.

ABSTRACT:

Background

Despite drastic improvement in overall survival for pediatric patients with cancer, those with osteosarcoma have stable rates of survival since the 1980s. This project evaluates the effect of several variables on survival after first recurrence in patients with osteosarcoma.

Methods

Data from three prospective North American cooperative group trials for newly diagnosed osteosarcoma are included: INT-0133, POG-9754, and AOST0121. The analytic population for this study is all enrolled patients with first event-free survival (EFS) event of relapse. The primary outcome measure for this retrospective analysis was survival after recurrence (SAR).

Results

The analytic population consisted of N = 431 patients. SAR was statistically significantly associated with age

SUBMITTER: Spraker-Perlman HL 

PROVIDER: S-EPMC6249072 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature