Incidence and risk of celiac disease after type 1 diabetes: A population-based cohort study using the health improvement network database.

ABSTRACT:

Objective

To determine the incidence of and risk factors for development of celiac disease (CD) in individuals with type 1 diabetes.

Methods

Cohort study using The Health Improvement Network (THIN), a UK primary care database of >13 million people. Individuals with incident type 1 diabetes diagnosed at 1 to 35 years of age between 1995 and 2015 with no previous diagnosis of CD were included. Cox regression was used to identify risk factors for CD, including age at diabetes diagnosis and sex, while adjusting for year of diagnosis to control for potential rising incidence in CD over time.

Results

Subjects (n = 9180; 43% female) had a median observation time of 5.1 years (interquartile range 2.0-10.1). CD was diagnosed in 196 (2%) during follow up. Median time to diagnos

SUBMITTER: Vajravelu ME 

PROVIDER: S-EPMC6249123 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature