Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.

ABSTRACT: Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca^2+</

SUBMITTER: Yu Y 

PROVIDER: S-EPMC6249158 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature