Analysis of Zika virus neutralizing antibodies in normal healthy Thais.

ABSTRACT: Zika virus (ZIKV) infections have been reported from all over Thailand, but the number of reported cases remains low, suggesting a degree of immune protection against ZIKV infection. To address this possibility, the presence of ZIKV neutralizing antibodies was determined in serum from 135 healthy Thai adults with a plaque reduction neutralization test (PRNT), and a number of samples were subsequently analyzed for the presence of neutralizing antibodies to dengue virus (DENV) and Japanese encephalitis virus (JEV). Results showed that 70.4% (PRNT₅₀ ≥ 10), 55.6 (PRNT₅₀ ≥ 20) or 22.2% (PRNT₉₀ ≥ 20) of the samples showed neutralizing antibodies to ZIKV. Detailed analysis showed no association between the presence of neutralizing antibodies to other flaviviruses

SUBMITTER: Sornjai W 

PROVIDER: S-EPMC6249253 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature