Cellular Electrophysiology of Iron-Overloaded Cardiomyocytes.

ABSTRACT: Iron, the most abundant transition metal element in the human body, plays an essential role in many physiological processes. However, without a physiologically active excretory pathway, iron is subject to strict homeostatic processes acting upon its absorption, storage, mobilization, and utilization. These intricate controls are perturbed in primary and secondary hemochromatoses, leading to a deposition of excess iron in multiple vital organs including the heart. Iron overload cardiomyopathy is the leading cause of mortality in patients with iron overload conditions. Apart from mechanical deterioration of the siderotic myocardium, arrhythmias reportedly contribute to a substantial portion of cardiac death associated with iron overload. Despite this significant impact, the cellular mechanis

SUBMITTER: Siri-Angkul N 

PROVIDER: S-EPMC6249272 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature