Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition.

ABSTRACT: Clinical benefits of pallidal deep brain stimulation (GPi DBS) in dystonia increase relatively slowly suggesting slow plastic processes in the motor network. Twenty-two patients with dystonia of various distribution and etiology treated by chronic GPi DBS and 22 healthy subjects were examined for short-latency intracortical inhibition of the motor cortex elicited by paired transcranial magnetic stimulation. The relationships between grey matter volume and intracortical inhibition considering the long-term clinical outcome and states of the GPi DBS were analysed. The acute effects of GPi DBS were associated with a shortening of the motor response whereas the grey matter of chronically treated patients with a better clinical outcome showed hypertrophy of the supplementary motor area and cere

SUBMITTER: Fecikova A 

PROVIDER: S-EPMC6249276 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature