Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia.

ABSTRACT:

Aim

We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia.

Methods

Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m²); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area und

SUBMITTER: Tada H 

PROVIDER: S-EPMC6249359 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature