Bioactive metabolites from the leaves of Withania adpressa.

ABSTRACT:

Context

Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties.

Objective

To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test them for their NF-κB inhibition and antiproliferative activity in multiple myeloma cells.

Materials and methods

Compounds were obtained from the EtOAc extract of W. adpressa leaves. Structure elucidation was carried out mainly by 1D- and 2D-NMR, and mass spectrometry. Isolated compounds were tested in a dose-response for their in vitro NF-κB inhibition and antiproliferative activity in multiple myeloma cells after 5 and 72 h treatment, respectively.

Results

The fractionation resulted in the isolation of a new glycowith

SUBMITTER: Ben Bakrim W 

PROVIDER: S-EPMC6249549 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature