Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures.

ABSTRACT:

Background

A need to develop therapeutics to treat Ebola virus disease patients in remote and resource-challenged settings remains in the wake of the 2013-2016 epidemic in West Africa. Toward this goal, we screened drugs under consideration as treatment options and other drugs of interest, most being small molecules approved by the Food and Drug Administration. Drugs demonstrating in vitro antiviral activity were advanced for evaluation in combinations because of advantages often provided by drug cocktails.

Methods

Drugs were screened for blockade of Ebola virus infection in cultured cells. Twelve drugs were tested in all (78 pair-wise) combinations, and 3 were tested in a subset of combinations.

Results

Multiple synergistic drug pairs emerged, with the majority compr

SUBMITTER: Dyall J 

PROVIDER: S-EPMC6249579 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature