Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease.

ABSTRACT:

Background

The pathophysiology of Ebola virus disease (EVD) is still poorly understood. This study aimed at identifying soluble biomarkers that inform on disease mechanisms.

Methods

Fifty-four soluble mediators of the immune, coagulation, and endothelial system were measured in baseline and follow-up samples from hospitalized patients with EVD, using Luminex technology. Cross-sectional expression levels and changes over time were correlated with outcome.

Results

Levels of circulating proinflammatory cytokines and chemokines, as well as markers of endothelial dysfunction and coagulopathy, were elevated on admission to hospital in patients who died from EVD as compared to survivors. These markers further increased in patients who died and/or decreased over time in survi

SUBMITTER: Kerber R 

PROVIDER: S-EPMC6249596 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature