New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model.

ABSTRACT: Previously, several studies have been performed to delineate the development and progression of Marburg virus infection in nonhuman primates (NHPs), primarily to clarify the mechanisms of severe (fatal) disease. After the 2013-2016 Ebola virus disease (EVD) epidemic in Western Africa, there has been a reassessment of the available filovirus animal models and the utility of these to faithfully recapitulate human disease. The high lethality of the NHP models has raised doubts as to their ability to provide meaningful data for the full spectrum of disease observed in humans. Of particular interest are the etiologic and pathophysiologic mechanisms underlying postconvalescent sequelae observed in human survivors of EVD and Marburg virus disease (MVD). In the current study, we evaluated the lesi

SUBMITTER: Cooper TK 

PROVIDER: S-EPMC6249607 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature