Association between lung cancer risk and inorganic arsenic concentration in drinking water: a dose-response meta-analysis.

ABSTRACT: High dose arsenic in drinking water (≥100 μg L^-1) is known to induce lung cancer, but lung cancer risks at low to moderate arsenic levels and its dose-response relationship remains inconclusive. We conducted a systematic review of cohort and case-control studies that quantitatively reported the association between arsenic concentrations in drinking water and lung cancer risks by searching the PubMed database till June 14, 2018. Pooled relative risks (RRs) of lung cancer associated with full range (10 μg L^-1-1000 μg L^-1) and low to moderate range (<100 μg L^-1) of water arsenic concentrations were calculated using random-effects models. A dose-response meta-analysis was performed to estimate the pooled associations between restricted cubic splines

SUBMITTER: Yuan T 

PROVIDER: S-EPMC6249628 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature