Acquired mechanisms of immune escape in cancer following immunotherapy.

ABSTRACT: Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape.

SUBMITTER: Iorgulescu JB 

PROVIDER: S-EPMC6249768 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature