Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.

ABSTRACT: Cytokinesis is a complicated yet conserved step of the cell-division cycle that requires the coordination of multiple proteins and cellular processes. Here we describe a previously uncharacterized protein, Ync13, and its roles during fission yeast cytokinesis. Ync13 is a member of the UNC-13/Munc13 protein family, whose animal homologues are essential priming factors for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex assembly during exocytosis in various cell types, but no roles in cytokinesis have been reported. We find that Ync13 binds to lipids in vitro and dynamically localizes to the plasma membrane at cell tips during interphase and at the division site during cytokinesis. Deletion of Ync13 leads to defective septation and exocytosis, uneven distributio

SUBMITTER: Zhu YH 

PROVIDER: S-EPMC6249806 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature