Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy.

ABSTRACT:

Background

Septic shock is the most severe complication of sepsis and this syndrome is associated with high mortality. Treatment of septic shock remains largely supportive of hemodynamics and tissue perfusion. Early changes in organ function assessed by the Sequential Organ Function Assessment (SOFA) score are highly predictive of the outcome. However, the individual patient's response to supportive therapy is very heterogeneous, and the mechanisms underlying this variable response remain elusive. The aim of the study was to investigate the transcriptome of whole blood in septic shock patients with different responses to early supportive hemodynamic therapy assessed by changes in SOFA scores within the first 48 h from intensive care unit (ICU) admission.

Methods

We performed

SUBMITTER: Barcella M 

PROVIDER: S-EPMC6249814 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature