A systematic review of non-standard dosing of oral anticancer therapies.

ABSTRACT:

Background

The use of oral systemic anticancer therapies (SACT) has increased and led to improved cancer survival outcomes, particularly with the introduction of small molecule targeted agents and immunomodulators. Oral targeted SACT are, however, associated with toxicities, which might result in reduced quality of life and non-adherence. To reduce treatment-related toxicity, the practice of non-standard dosing is increasing; however guidance to govern this practice is limited. A systematic review was conducted to identify evidence of, and outcomes from, non-standard dosing of oral SACT in oncology and malignant haematology.

Methods

A comprehensive search of 78 oral SACT was conducted in the following databases: MEDLINE®, EMBASE®, Cochrane Library©, and Cumulative Index to N

SUBMITTER: Djebbari F 

PROVIDER: S-EPMC6249819 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature