Rap1 GTPase promotes coordinated collective cell migration in vivo.

ABSTRACT: During development and in cancer, cells often move together in small to large collectives. To move as a unit, cells within collectives need to stay coupled together and coordinate their motility. How cell collectives remain interconnected and migratory, especially when moving through in vivo environments, is not well understood. The genetically tractable border cell group undergoes a highly polarized and cohesive cluster-type migration in the Drosophila ovary. Here we report that the small GTPase Rap1, through activation by PDZ-GEF, regulates border cell collective migration. We find that Rap1 maintains cell contacts within the cluster, at least in part by promoting the organized distribution of E-cadherin at specific cell-cell junctions. Rap1 also restricts migratory protrusions to the fr

SUBMITTER: Sawant K 

PROVIDER: S-EPMC6249841 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature