Glomerular filtration rate: new age- and gender- specific reference ranges and thresholds for living kidney donation.

ABSTRACT:

Background

There is a need for a large, contemporary, multi-centre series of measured glomerular filtration rates (mGFR) from healthy individuals to determine age- and gender-specific reference ranges for GFR. We aimed to address this and to use the ranges to provide age- and gender-specific advisory GFR thresholds considered acceptable for living kidney donation.

Methods

Individual-level data including pre-donation mGFR from 2974 prospective living kidney donors from 18 UK renal centres performed between 2003 and 2015 were amalgamated. Age- and gender-specific GFR reference ranges were determined by segmented multiple linear regression and presented as means ± two standard deviations.

Results

Males had a higher GFR than females (92.0 vs 88.1 mL/min/1.73m²,

SUBMITTER: Fenton A 

PROVIDER: S-EPMC6249883 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature