Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of tissue-specific cellular functions and have been shown to regulate transcriptional and translational processes, acting as signals, decoys, guides, and scaffolds. It has been suggested that some lncRNAs act in cis to regulate the expression of neighboring protein-coding genes (PCGs) in a mechanism that fine-tunes gene expression. Gut microbiome is increasingly recognized as a regulator of development, inflammation, host metabolic processes, and xenobiotic metabolism. However, there is little known regarding whether the gut microbiome modulates lncRNA gene expression in various host metabolic organs. The goals of this study were to 1) characterize the tissue-specific expression of lncRNAs and 2) id

SUBMITTER: Dempsey J 

PROVIDER: S-EPMC6249886 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature