Impact of timing of continuous intravenous anesthetic drug treatment on outcome in refractory status epilepticus.

ABSTRACT:

Background

Patients in refractory status epilepticus (RSE) may require treatment with continuous intravenous anesthetic drugs (cIVADs) for seizure control. The use of cIVADs, however, was recently associated with poor outcome in status epilepticus (SE), raising the question of whether cIVAD therapy should be delayed for attempts to halt seizures with repeated non-anesthetic antiepileptic drugs. In this study, we aimed to determine the impact of differences in therapeutic approaches on RSE outcome using timing of cIVAD therapy as a surrogate for treatment aggressiveness.

Methods

This was a retrospective cohort study over 14 years (n = 77) comparing patients with RSE treated with cIVADs within and after 48 h after RSE onset, and functional status at last follow-up was the prim

SUBMITTER: Madzar D 

PROVIDER: S-EPMC6249897 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature