Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children.

ABSTRACT:

Background

Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships.

Methods

Children underwent home collections of nasal lavage during scheduled surveillance periods and self-reported respiratory illnesses. We studied 53 children for one year, analyzing 392 surveillance samples and 203 samples from 85 respiratory illnesses. Generalized estimated equations were used to evaluate associations between nasal lavage biomarkers (7 mRNAs, 10 proteins), lung function and viral infection.

Results

As anticipated, viral infection was associated with increased cytokines and reduced FVC and FEV₁. However, we found frequent

SUBMITTER: Lewis TC 

PROVIDER: S-EPMC6249926 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature