Drug repositioning using drug-disease vectors based on an integrated network.

ABSTRACT:

Background

Diverse interactions occur between biomolecules, such as activation, inhibition, expression, or repression. However, previous network-based studies of drug repositioning have employed interaction on the binary protein-protein interaction (PPI) network without considering the characteristics of the interactions. Recently, some studies of drug repositioning using gene expression data found that associations between drug and disease genes are useful information for identifying novel drugs to treat diseases. However, the gene expression profiles for drugs and diseases are not always available. Although gene expression profiles of drugs and diseases are available, existing methods cannot use the drugs or diseases, when differentially expressed genes in the profiles are not in

SUBMITTER: Lee T 

PROVIDER: S-EPMC6249928 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature