Weight Loss Induced by Bariatric Surgery Restricts Hepatic GDF15 Expression.

ABSTRACT:

Introduction

Obesity and related nonalcoholic fatty liver disease (NAFLD) are an emerging health care issue that imposes substantial morbidity to individuals. Growth and differentiation factor 15 (GDF15) limits food uptake, body weight, and energy balance by modulation of GDNF-family receptor α-like (GFRAL) signalling in the hindbrain. However, the regulation of GDF15 expression in obesity and NAFLD is incompletely understood. We sought to define the impact of weight loss achieved by laparoscopic adjustable gastric banding (LAGB) on hepatic and adipose GDF15 expression in a cohort of severely obese patients.

Methods

We analysed GDF15 expression of liver and subcutaneous adipose tissue before and 6 months after LAGB in severely obese patient

SUBMITTER: Adolph TE 

PROVIDER: S-EPMC6250003 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature