Deletion of 3p13 is a late event linked to progression of TMPRSS2:ERG fusion prostate cancer.

ABSTRACT:

Introduction

Deletion of 3p13 is one of the most common alterations in prostate cancer preferentially occurring in tumors with TMPRSS2:ERG fusion. The cause for the striking association between 3p13 loss and ERG fusion is unknown.

Methods

Here, we made use of a preexisting heterogeneity prostate cancer tissue microarray including ten tissue spots from ten different tumor areas of 317 cancers to examine the spatial distribution of 3p13 deletions (determined by fluorescence in situ hybridization) in prostate cancer areas with and without ERG overexpression (determined by immunohistochemistry).

Results

3p13 deletions were found in 61 of 299 (20.4%) and ERG positivity in 174 of 317 (54.9%) interpretable cancers. The likelihood of 3p13 loss was twice as high

SUBMITTER: Kluth M 

PROVIDER: S-EPMC6250107 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature